Premium
Evidence for a factor promoting the conversion of VWF from low and intermediate to high molecular mass polymers on the platelet membrane
Author(s) -
Ferri A.,
Guerra S.,
Gemmati D.,
Chiozzi P.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80659-3
Subject(s) - von willebrand factor , molecular mass , platelet , glycoprotein , chemistry , platelet membrane glycoprotein , membrane , polymer , biophysics , biochemistry , immunology , biology , organic chemistry , enzyme
On the membrane surface of resting platelets exists a factor capable of promoting the conversion of plasma von Willebrand factor from low and intermediate molecular mass to high molecular mass polymers. The process is accompanied by a parallel increase in the von Willebrand factor activity. This could be a regulatory system for the molecular mass distribution of von Willebrand factor during its lifetime in plasma. Glycoprotein Ib of the platelet membrane appears not to be involved in the process.