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Transforming growth factors β1 and β2 as well as milk growth factor decrease anti‐CD3‐induced proliferation of human lymphocytes without inhibiting the anti‐CD3‐mediated increase of [Ca 2+ ] i and the activation of protein kinase C
Author(s) -
Stoeck Michael,
Sommermeyer Henning,
Miescher Sylvia,
Cox David,
Alkan Sefik,
Szamel Marta
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80643-x
Subject(s) - growth factor , transforming growth factor , cd3 , biology , medicine , endocrinology , chemistry , microbiology and biotechnology , immunology , biochemistry , antigen , receptor , cd8
Porcine transforming growth factor 1 and 2 (pTGF‐β1 and ‐β2) and milk growth factor (MGF) at 1 ng/ml significantly inhibited the proliferation of human lymphocytes induced by anti‐CD3 antibodies. In contrast, the anti‐CD3‐mediated increase of intracellular Ca 2+ and the activation and translocation of protein kinase C were not affected by the transforming growth factors.