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Immunological evidence for a relationship between the dendrotoxin‐binding protein and the mammalian homologue of the Drosophila Shaker K + channel
Author(s) -
Rehm Hubert,
Newitt Richard A.,
Tempel Bruce L.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80628-3
Subject(s) - shaker , chemistry , microbiology and biotechnology , biophysics , genetics , biology , physics , acoustics , vibration
Polyclonal antibodies were raised against two synthetic peptides from different parts of the predicted amino acid sequence of the mouse homologue (MBK1) of the Drosophila Shaker K + channel. The antibodies recognized the toxin‐binding subunit of the dendrotoxin‐binding proteins from rat and bovine brain. The results suggest that the dendrotoxin‐binding protein is related to the expression products of the mammalian homologue of the Shaker gene.