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Forskolin stimulates pinealocyte cGMP accumulation Dramatic potentiation by an α 1 ‐adrenergic → [Ca 2+ ] i mechanism involving protein kinase C
Author(s) -
Ho Anthony K.,
Chik Constance L.,
Klein David C.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80625-8
Subject(s) - pinealocyte , forskolin , pde10a , protein kinase a , medicine , endocrinology , stimulation , adrenergic , signal transduction , long term potentiation , protein kinase c , chemistry , microbiology and biotechnology , receptor , kinase , biology , enzyme , biochemistry , pineal gland , phosphodiesterase , melatonin
The effect of forskolin on cGMP regulation was investigated using dispersed rat pinealocytes. Forskolin stimulated cGMP accumulation in a concentration‐dependent manner; this response was strongly potentiated by an α 1 ‐adrenergic → [Ca 2+ ] i mechanism involving protein kinase C. These findings provide further evidence that activation of two receptor‐regulated signal transduction mechanisms may be commonly required for maximal stimulation of cGMP accumulation, and establish a new experimental approach to the study of cGMP regulation.