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Family of human Na + ,K + ‐ATPase genes Structure of the putative regulatory region of the α + ‐gene
Author(s) -
Sverdlov E.D.,
Bessarab D.A.,
Malyshev I.V.,
Petrukhin K.E.,
Smirnov Yu.V.,
Ushkaryov Yu.A.,
Monastyrskaya G.S.,
Broude N.E.,
Modyanov N.N.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80588-5
Subject(s) - gene , coding region , biology , exon , nucleotide , nucleic acid sequence , protein primary structure , gene family , genetics , microbiology and biotechnology , regulatory sequence , genome , peptide sequence , regulation of gene expression
The primary structure of the putative regulatory region of a gene of the Na + ,K + ‐ATPase multigene family in the human genome has been determined. This region includes the first exon with all of the untranslatable sequence of mRNA and a dozen nucleotides, coding for the first four amino acids of the hypothetic precursor of the α + ‐subunit. The entire region comprises over 1400 bp. The possible role of specific nucleotide blocks within this region in comparison with other genes is discussed.