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Inhibition of myeloid differentiation by inhibitors of ADP‐ribosylation
Author(s) -
Wu Ming-chi,
Zaun M.Rebecca,
Wu Fu-Mei
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80558-7
Subject(s) - myeloid , adp ribosylation , chemistry , pharmacology , microbiology and biotechnology , cancer research , biology , biochemistry , enzyme , nad+ kinase
Inhibitors of ADP‐ribosylation inhibited the myeloid differentiation of murine myelomonocytic leukemia WEHI‐3BD + cells induced by granulocyte colony‐stimulating factor. Benzamide, at 2.0 mM, inhibited 50% of the WEHI‐3BD + cell differentiation but had no significant effect on the proliferation. However, benzylaminododecylguanine hydrochloride and p ‐methoxylbenzylaminodecamethylene guanidine sulfate at 2.0 and 2.2 μM, respectively, inhibited 50% of proliferation but had no effect at all on differentiation. The differential effects of inhibitors provide a model to study the role of ADP‐ribosylation in myeloid differentiation.