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Human recombinant interleukin‐ 1α increases biosynthesis of collagenase and hyaluronic acid in cultured human chorionic cells
Author(s) -
Katsura Morimasa,
Ito Akira,
Hirakawa Shun,
Mori Yo
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80553-8
Subject(s) - collagenase , hyaluronic acid , glycosaminoglycan , biosynthesis , fibroblast , biochemistry , chemistry , secretion , connective tissue , fetal membrane , fetus , biology , enzyme , in vitro , pregnancy , placenta , anatomy , genetics
The influence of human recombinant interleukin‐1α (hrIL‐1) on biosynthesis of collagenase and glycosaminoglycans was investigated with fibroblast‐like cells of human chorionic membrane. hrIL‐1 stimulated cells to produce procollagenase in a dose‐dependent manner. Furthermore, it similarly accelerated both biosynthesis and secretion of hyaluronic acid in chorionic cells, but did not modulate the biosynthesis of sulfated glycosaminoglycans. Therefore, the relative concentration of hyaluronic acid vs total glycosaminoglycans increased significantly. These results are connected with the decrease in tensile strength observed in ruptured fetal membranes. Thus, it is proposed that IL‐1 from effused leukocytes in fetal membranes plays an important role in connective tissue metabolism, especially in premature rupture of membranes with chorioamnionitis.