Premium
Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions
Author(s) -
Kloog Y.,
Ambar I.,
Kochva E.,
Wollberg Z.,
Bdolah A.,
Sokolovsky M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80507-1
Subject(s) - receptor , hydrolysis , chemistry , microbiology and biotechnology , biochemistry , neuroscience , biophysics , biology
Sarafotoxin‐b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin‐b induced PI hydrolysis is largely independent of extracellular Ca 2+ and is detected in all brain regions where toxin‐binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.