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Stimulation of transcription from different RNA polymerase II promoters by high mobility group proteins 1 and 2
Author(s) -
Tremethick David J.,
Molloy Peter L.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80499-5
Subject(s) - promoter , rna polymerase ii , transcription factor ii d , transcription (linguistics) , transcription factor ii b , transcription factor ii f , general transcription factor , microbiology and biotechnology , response element , biology , rna polymerase , transcription factor ii a , chemistry , rna , gene expression , genetics , gene , linguistics , philosophy
High mobility group proteins (HMGs) 1 and 2 are shown to stimulate transcription in vitro from a number of RNA polymerase II promoters. Greatest effects were seen on transcription from the SV40 late promoter, then the SV40 early promoter with similar levels of transcription enhancement being seen for the human metallothionein 2A, adenovirus major late and chicken feather keratin promoters. The results indicate that HMGs 1 and 2 act to increase initiation of transcription in vitro and differential effects on the promoters are consistent with their action being in part to enhance the binding or functional activity of promoter‐specific transcription factors.