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Protein kinase C is involved in regulation of Ca 2+ channels in plasmalemma of Nitella syncarpa
Author(s) -
Zherelova O.M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80495-8
Subject(s) - nitella , biophysics , staurosporine , protein kinase c , chemistry , protein kinase a , intracellular , microbiology and biotechnology , biochemistry , biology , kinase
Ca 2+ current recordings have been made on Nitella syncarpa cells using the intracellular perfusion and the voltage‐clamp technique. TPA (12‐ O ‐tetradecanoylphorbol‐13‐acetate), a substance capable of activating protein kinase C from plasmalemma of Nitella cells, modulates voltage‐dependent Ca 2+ channels. Polymixin B, inhibitor of protein kinase C, blocks the Nitella plasmalemma Ca 2+ channels; the rate of channel blockage depends on the concentration and exposure time of the substance.