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Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes
Author(s) -
Castell José V.,
Gómez-Lechón Maria J.,
David Martina,
Andus Tilo,
Geiger Thomas,
Trullenque Ramón,
Fabra Ricardo,
Heinrich Peter C.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80476-4
Subject(s) - acute phase protein , haptoglobin , transferrin , serum amyloid a , albumin , fibrinogen , secretion , tumor necrosis factor alpha , interleukin , blood proteins , chemistry , alpha (finance) , medicine , endocrinology , inflammation , biology , cytokine , construct validity , nursing , patient satisfaction
The three monokines interleukin‐1β (IL‐1β), tumor necrosis factor α (TNFα), and interleukin‐6 (IL‐6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL‐6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e. synthesis and secretion of C‐reactive protein, serum amyloid A, fibrinogen, α 1 ‐antitrypsin, α 1 ‐antichymotrypsin and haptoglobin are increased while albumin, transferrin and fibronectin are decreased. IL‐1β as well as TNFα, although having a moderate effect on the positive acute phase proteins and inhibiting the synthesis of fibrinogen, albumin and transferrin, fail to induce serum amyloid A and C‐reactive protein. These data suggest that IL‐6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.