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A unique signature identifies a family of zinc‐dependent metallopeptidases
Author(s) -
Jongeneel C.Victor,
Bouvier Jacques,
Bairoch Amos
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80471-5
Subject(s) - zinc , signature (topology) , sequence (biology) , sequence motif , peptide sequence , computational biology , biology , zinc finger , protein family , protein sequencing , chemistry , biochemistry , gene , mathematics , geometry , organic chemistry , transcription factor
The primary sequence motif HExxH has been found in many zinc‐dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc‐dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.