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Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults Effect of starvation and thyroxine treatment
Author(s) -
Freund J.-N.,
Duluc I.,
Raul F.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80427-2
Subject(s) - lactase , starvation , endocrinology , medicine , messenger rna , enzyme , biology , chemistry , biochemistry , gene
The accumulation profile of intestinal lactase mRNA was investigated in suckling and adult rats and pigs. We found no correlation between the lactase enzymatic activity and the accumulation of the messenger at both developmental stages. Modulation of lactase activity by starvation or thyroxine treatment had no effect on lactase mRNA accumulation in the rat intestine. These results confirm that thyroxine modulates lactase expression essentially at the post‐transcriptional level.