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Prosomes discriminate between mRNA of adenovirus‐infected and uninfected HeLa cells
Author(s) -
Horsch Andrea,
de Sa Cezar Martins,
Dineva Bistra,
Spindler Ernst,
Schmid Hans-Peter
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80268-6
Subject(s) - hela , messenger rna , translation (biology) , rna , in vitro , cytoplasm , microbiology and biotechnology , biology , protein biosynthesis , chemistry , gene , biochemistry
Prosomes are small cytoplasmic RNP complexes associated with repressed mRNA. In in vitro translation, they discriminate between the mRNA of adenovirus‐infected HeLa cells and those of uninfected cells grown under normal conditions. Prosomes as well as their RNA constituents interact much more strongly with poly(A) + mRNA of infected cells and inhibit their translation in vitro preferentially. A possible role of prosomes in the differential regulation of translation is discussed.