Premium
Modelling basic features of specificity in DNA‐aureolic acid‐derived antibiotic interactions
Author(s) -
Chen K.-X.,
Gresh N.,
Hui X.,
Pullman B.,
Zakrzewska K.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80209-1
Subject(s) - guanine , oligonucleotide , aglycone , dna , stereochemistry , chemistry , groove (engineering) , minor groove , biochemistry , nucleotide , materials science , glycoside , metallurgy , gene
The nonintercalative groove binding of a simplified model of olivomycin, to sequences d(CGCGCGC) 2 , d(TATATAT) 2 , and d(CICICIC) 2 , is investigated. A significant preference is displayed for the minor groove of the d(CG) sequence. This is due predominantly to the formation of H‐bonds between the hydroxyl groups on the aglycone of the drug and the 2‐amino group of the central guanine of the oligonucleotide.