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Interferon (IFN)‐like antiviral effect is induced by unspecific cross‐linking of cell surface receptors
Author(s) -
Premecz György,
Markovits Andrea,
Bagi György,
Farkas Tibor,
Földes István
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80143-7
Subject(s) - vesicular stomatitis virus , interferon , receptor , cytopathic effect , cell , virology , cell surface receptor , biology , chemistry , microbiology and biotechnology , virus , biochemistry
Treatment of human amniotic cells (UAC) with Cytodex 1 (DEAE‐dextran) results in the development of an antiviral state of the cells, as proven by studying (i) the cytopathic effect and (ii) [ 3 H]uridine incorporation into the RNA of vesicular stomatitis virus (VSV) after VSV infection. The same treatment transiently triggers the breakdown of inositol phospholipids and activates the translocation of protein kinase C (PKC). On the basis of these data it can be suggested that cross‐linking of cell surface receptors by a solid carrier bearing covalently bound positive charges may result in IFN‐like effects.