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Expression of the SmB′ splicing protein in rodent cells capable of following an alternative RNA splicing pathway
Author(s) -
Sharpe Neil G.,
Williams David G.,
Norton Pamela,
Latchman David S.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80114-0
Subject(s) - spliceosome , rna splicing , rna , alternative splicing , biology , protein expression , microbiology and biotechnology , cell , rna binding protein , messenger rna , genetics , gene
The expression of the SmB and SmB′ spliceosome proteins in a variety of cell types and tissues has been investigated. Although SmB is found in all cells studied, the SmB′ protein is found only in a small number of rodent cell types. The presence of this protein is correlated with the ability to utilize an alternative pathway of RNA splicing which is not available in most cell types. This is the first demonstration of tissue specific expression of a protein component of the spliceosome and suggests a role for SmB′ in the regulation of some cases of alternative RNA splicing.