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Activation of chloride channels in the plasmalemma of Nitella syncarpa by inositol 1,4,5‐trisphosphate
Author(s) -
Zherelova O.M.
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80025-0
Subject(s) - nitella , inositol , biophysics , chemistry , intracellular , chloride channel , biochemistry , biology , receptor
The introduction of 1.5 × 10 −8 − 10 −6 M inositol 1,4,5‐trisphosphate (IP 3 ) into the bathing solution of Nitella syncarpa cells induced: (i) an increase in amplitude of the inward Ca 2+ current; (ii) the appearance of an inward Cl − current; (iii) a shift in the threshold for activation of the Cl − channels on hyperpolarization of the membrane to more positive values. These facts suggest that IP 3 participates in the causing of changes in the intracellular free Ca 2+ concentration and, hence, in the regulation of ionic channels in Nitella syncarpa plasmalemma.