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Role of the carboxyl‐terminal region of the PVP protein (F 0 I subunit) in the H + conduction of F 0 F 1 H + ‐ATP synthase of bovine heart mitochondria
Author(s) -
Papa Sergio,
Guerrieri Ferruccio,
Zanotti Franco,
Houštěk Josef,
Capozza Giuseppe,
Ronchi Severino
Publication year - 1989
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(89)80016-x
Subject(s) - terminal (telecommunication) , protein subunit , chemistry , crystallography , physics , biochemistry , computer science , gene , telecommunications
By means of protein sequencing, labelling with thiol reagents and reconstitution studies it is shown that the carboxyl‐terminal region of the PVP protein (F 0 I subunit, nuclear‐encoded protein of M r 25000) of mitochondrial F 0 promotes transmembrane proton conduction by F 0 and the sensitivity of this process to oligomycin.