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α‐Melanocyte stimulating hormone promotes neurite outgrowth in chromaffin cells
Author(s) -
Demeneix Barbara,
Grant Nancy J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81450-9
Subject(s) - neurite , chromaffin cell , adrenal medulla , endocrinology , melanocyte stimulating hormone , microbiology and biotechnology , neurotrophin , medulla , medicine , cell culture , biology , chemistry , hormone , in vitro , receptor , catecholamine , biochemistry , genetics
Chromaffin cells from adult bovine adrenal medulla were found to develop neurites when cocultured with pituitary intermediate lobe (IL) cells. In coculture 51.7% of the chromaffin cells extended neurites compared with 12% in control cultures (chromaffin cells alone). A soluble factor released by IL cells was apparently involved as medium conditioned by contact with IL cells also promoted neurite outgrowth. Moreover, the addition of αMSH, one of the pro‐opiomelanocortin‐derived peptides secreted by IL cells, alone reproduced this effect in a dose‐dependent manner. The data provide evidence for a neurotrophic role of αMSH.