Premium
Tuftsin stimulates growth of HL60 cells
Author(s) -
Bump Nancy J.,
Najjar Victor A.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81444-3
Subject(s) - tuftsin , phagocytosis , motility , thymidine , uridine , stimulation , chemistry , hl60 , monocyte , macrophage , granulocyte , microbiology and biotechnology , biochemistry , biology , immunology , in vitro , endocrinology , rna , peptide , gene
Many functions of monocyte/macrophage and granulocyte are activated by tuftsin; principally phagocytosis, motility, immunogenic stimulation, antibacterial and antineoplastic activities. Here it is shown that tuftsin stimulates HL60 growth to twice the control rate. The uptake of [ 3 H]uridine and [ 3 H]leucine in a pulse of 30 min was also double that of the control. The uptake of thymidine was not stimulated.