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Superoxide‐induced deimination of arginine in hematopoietic cells
Author(s) -
Kamoun P.P.,
Schneider E.,
Dy M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81440-6
Subject(s) - citrulline , citrullination , superoxide , arginine , chemistry , ornithine , microbiology and biotechnology , haematopoiesis , arginine deiminase , biochemistry , bone marrow , nitric oxide , biology , amino acid , enzyme , immunology , stem cell , organic chemistry
Murine bone marrow cells can produce citrulline directly from L‐arginine without intermediate ornithine. An L‐arginine‐dependent biochemical pathway synthesizing L‐citrulline and nitrate, coupled to an effector mechanism has also been recently demonstrated in murine cytotoxic activated macrophages. We show herein that L‐citrulline synthesis in murine bone marrow cells can be induced by the generation of superoxide. It can take place in an arginine‐free medium, suggesting the implication of a superoxide‐dependent peptidyl arginine deiminase.