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Prothymosin α is a nuclear protein
Author(s) -
Gómez-Márquez Jaime,
Segade Fernando
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81425-x
Subject(s) - thymosin , nucleus , nuclear protein , nuclear localization sequence , cell nucleus , microbiology and biotechnology , nuclear transport , immune system , cell , chemistry , biology , biochemistry , immunology , gene , transcription factor
Prothymosin α, a protein first isolated from rat thymus and widely distributed in animal tissues, has an attributed role in the stimulation of the immune system. Its structure contains thymosin α 1 , a Glu‐rich domain and a putative nuclear location signal. Furthermore, the amount of this protein seems to be associated with the relative size of the nucleus and is inducible during cell growth. We postulate that prothymosin α is located inside the cell nucleus and that its activity might be to organize some protein complexes.