Premium
Identification of novel GTP‐binding proteins in the human neutrophil
Author(s) -
Bokoch Gary M.,
Parkos Charles A.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81415-7
Subject(s) - gtp' , gtp binding protein regulators , g protein , pertussis toxin , biochemistry , gtpase activating protein , dna binding protein , nucleotide , chemistry , biology , guanine , receptor , enzyme , gene , transcription factor
We describe here the existence of previously undescribed GTP‐binding proteins within the human neutrophil. These proteins specifically bind guanine nucleotides under conditions in which the previously characterized G‐proteins are unable to bind. We have partially purified these proteins and present both functional and immunologic data which indicate that they are unrelated to G n , the major neutrophil pertussis toxin substrate. An additional protein, of apparent molecular mass 22 kDa, may be related to the ras G‐protein family. Analysis of the structural and functional characteristics of these novel proteins will promote a better understanding of the process of neutrophil activation.