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Rabbit cardiac and slow‐twitch muscle express the same phospholamban gene
Author(s) -
Fujii Junichi,
Lytton Jonathan,
Tada Michihiko,
MacLennan David H.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81412-1
Subject(s) - phospholamban , complementary dna , untranslated region , rabbit (cipher) , cardiac muscle , biology , gene , microbiology and biotechnology , nucleic acid sequence , amino acid , chemistry , messenger rna , biochemistry , endoplasmic reticulum , anatomy , statistics , mathematics
The nucleotide sequences of cDNAs encoding phospholamban were found to be virtually identical when the cDNA clones were isolated from rabbit slow‐twitch (soleus) and rabbit cardiac muscle libraries. These findings demonstrate that both types of muscle express the same phospholamban gene. The deduced amino acid sequences of rabbit and dog phospholamban were identical except for a change from Asp (dog) to Glu (rabbit) at position 2. The nucleotide sequences of the 5′‐ and the very long 3′‐untranslated regions of rabbit and dog phospholamban cDNAs also exhibited a high percentage of identity.