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Right atrial dilatation increases inositol‐(1,4,5)trisphosphate accumulation Implications for the control of atrial natriuretic peptide release
Author(s) -
von Harsdorf R.,
Lang R.,
Fullerton M.,
Smith A.I.,
Woodcock E.A.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81384-x
Subject(s) - inositol , atrial natriuretic peptide , medicine , phosphatidylinositol , stimulation , chemistry , atrium (architecture) , endocrinology , mammalian heart , right atrium , left atrium , cardiology , atrial fibrillation , receptor , signal transduction , biochemistry
Stretching the right atrium of isolated perfused [ 3 H]inositol‐labelled rat hearts was shown to stimulate the phosphatidyl‐inositol turnover pathway as demonstrated by the accumulation of [ 3 H]inositol‐(1,4,5)trisphosphate and its degradation products. Stimulation was detectable after 1 min with larger increases observed after 10 or 20 min. These findings demonstrate that the myocardium can respond to dilatation by an activation of the phosphatidylinositol turnover pathway. Such a mechanism has implications for the release of atrial natriuretic peptide following right atrial distention.