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Tissue specific opsonins for phagocytic cells and their different affinity for cholesterol‐rich liposomes
Author(s) -
Moghimi S.Moein,
Patel Harish M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81372-3
Subject(s) - opsonin , liposome , phagocytosis , cholesterol , chemistry , microbiology and biotechnology , biochemistry , biology
In accordance with the finding of our in vivo experiments reported earlier [(1983) Biochim. Biophys. Acta 761, 142–157 (1986) Biochim. Biophys. Acta 888, 184–190], the results of in vitro experiments show that Kupffer cells avidly take up cholesterol‐poor but not cholesterol‐rich liposomes, whereas splenic phagocytic cells take up preferentially cholesterol‐rich rather than cholesterol‐poor liposomes in the presence of serum. Evidence presented here suggests that serum contains opsonins specific for hepatic and splenic phagocytic cells and these opsonins have different affinities for cholesterol‐rich and cholesterol‐poor liposomes.