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Family of human Na + ,K + ‐ATPase genes Structure of the gene for the catalytic subunit (αIII‐form) and its relationship with structural features of the protein
Author(s) -
Ovchinnikov Yu.A.,
Monastyrskaya G.S.,
Broude N.E.,
Ushkaryov Yu.A.,
Melkov A.M.,
Smirnov Yu.V.,
Malyshev I.V.,
Allikmets R.L.,
Kostina M.B.,
Dulubova I.E.,
Kiyatkin N.I.,
Grishin A.V.,
Modyanov N.N.,
Sverdlov E.D.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81361-9
Subject(s) - gene , exon , protein subunit , intron , scn3a , coding region , microbiology and biotechnology , protein primary structure , structural gene , genetics , biology , gene family , genome , chemistry , g alpha subunit , peptide sequence , mutant
The primary structure of a gene of the Na + ,K + ‐ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII‐form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.