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Atrial natriuretic peptide (ANP) in rat gastrointestinal tract
Author(s) -
Vuolteenaho O.,
Arjamaa O.,
Vakkuri O.,
Maksniemi T.,
Nikkilä L.,
Kangas J.,
Puurunen J.,
Ruskoaho H.,
Leppäluoto J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81359-0
Subject(s) - atrial natriuretic peptide , gastrointestinal tract , small intestine , stomach , medicine , endocrinology , chemistry , peptide , biochemistry
Acid extracts of rat stomach and small intestine contained 8.6 ± 3.7 and 39 ± 15 ng/g of immunoreactive atrial natriuretic peptide (ANP). When studied by gel filtration and reverse‐phase high‐performance liquid chromatography, the stomach immunoreactivity consisted of multiple components, whereas the small intestine contained mostly proANP and ANP 1–28‐like material. These findings indicate that ANP may have a role in the physiology of the gastrointestinal tract, e.g. in the regulation of water and electrolyte absorption.