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A third human CALC (pseudo)gene on chromosome 11
Author(s) -
Höppener J.W.M.,
Steenbergh P.H.,
Zandberg J.,
Adema G.J.,
van Kessel A.H.M.Geurts,
Lips C.J.M.,
Jansz H.S.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81355-3
Subject(s) - pseudogene , exon , gene , genetics , biology , locus (genetics) , calcitonin gene related peptide , chromosome , human genome , microbiology and biotechnology , genome , receptor , neuropeptide
A genomic locus in man (CALC‐III) containing nucleotide sequences highly homologous to both exon 2 and exon 3 of the CALC‐I and ‐II genes, is described in this paper. The CALC‐I gene produces calcitonin (CT) (encoded by exon 4) or calcitonin gene‐related peptide (CGRP) (encoded by exon 5) in a tissue‐specific fashion. The CALC‐II gene produces a second human CGRP, but probably not a second CT. The CALC‐III gene does not seem to encode a CT‐ or CGRP‐related polypeptide hormone and is probably a pseudogene. Like the other two CALC genes, the CALC‐III gene is located on human chromosome 11.