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Periportal and perivenous hepatocytes respond equally to glycogenolytic agonists
Author(s) -
Keppens Stefaan,
De Wulf Henri
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81353-x
Subject(s) - chemistry , microbiology and biotechnology , biochemistry , biology
We have used the technique of short‐term infusion with digitonin to obtain hepatocytes originating either from the periportal or the perivenous zone of the liver acinus [(1985) Biochem. J. 229, 221–226]. Total glycogen phosphorylase content and sensitivity to cyclic AMP‐dependent and calcium‐mediated glycogenolytic agonists were very similar for both cell sub‐populations and did not differ from the values obtained for control cells. We conclude therefore that there is an apparent absence of metabolic zonation as far as receptor‐mediated glycogenolysis and glycogenolytic potency is concerned.