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Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells
Author(s) -
Corcos Laurent,
Weiss Mary C.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81351-6
Subject(s) - phenobarbital , dexamethasone , benzanthracene , cytochrome p450 , cytochrome , medicine , chemistry , pharmacology , endocrinology , biology , biochemistry , enzyme , carcinogen
Hepatoma cells derived from the Reuber H35 rat hepatoma express cytochrome P450 enzymes of two major families: polycyclic aromatic hydrocarbon‐inducible forms are found in both differentiated and dedifferentiated cells while phenobarbital (PB)‐inducible forms are found only in differentiated cells. We report here that (i) benzanthracene and PB induce P450 c mRNA in differentiated and dedifferentiated cells and (ii) dexamethasone and PB induce P450 b/e and/or P450 PB1 mRNAs in differentiated cells but not in dedifferentiated cells.