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Long‐term ingestion of ammonium inhibits lysosomal proteolysis in rat liver
Author(s) -
Felipo Vicente,
Miñana María-Dolores,
Wallace Ruth,
Grisolía Santiago
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81336-x
Subject(s) - proteolysis , ingestion , chemistry , term (time) , biochemistry , ammonium , enzyme , organic chemistry , physics , quantum mechanics
A standard diet was supplemented with ammonium acetate (20%, w/w). The effect on liver protein degradation of oral administration of the ammonium diet to rats for 6 weeks has been studied. It is shown that lysosomal proteolysis is markedly decreased (by 62%) while non‐lysosomal proteolysis is inhibited by 11%. This is the first report showing that ammonium ingestion inhibits liver proteolysis.