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Phospholipase activation, free fatty acids and the proton permeability of a biological membrane
Author(s) -
Lachowiez Robert M.,
Hammoud Nasser M.,
Teibel Jeffrey L.,
Dix James A.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81332-2
Subject(s) - chemistry , phospholipase , biophysics , permeability (electromagnetism) , oleic acid , phospholipase c , calcium , phospholipase a2 , membrane , biochemistry , enzyme , biology , organic chemistry
The rate of collapse of a proton gradient across the apical membrane of rat kidney proximal tubule increases upon treatment with calcium, mercuric chloride and mellitin, substances which activate phospholipase A 2 . Treatment with phospholipase A 2 or oleic acid also enhances the rate of proton gradient dissipation. Membrane water permeability is not affected. This phenomenon may have implications in pathological states arising from ischemia or toxic exposure.