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Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes
Author(s) -
Redini F.,
Galera P.,
Mauviel A.,
Loyau G.,
Pujol J.-P.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81327-9
Subject(s) - glycosaminoglycan , transforming growth factor , cartilage , chemistry , transforming growth factor beta , matrix (chemical analysis) , microbiology and biotechnology , growth factor , extracellular matrix , stimulation , transforming growth factor, beta 3 , articular cartilage , chondrocyte , endocrinology , medicine , biochemistry , biology , anatomy , in vitro , osteoarthritis , tgf alpha , pathology , receptor , alternative medicine , chromatography
The effect of transforming growth factor β (TGF‐β) on the production of matrix macromolecules was studied in cultures of rabbit articular chondrocytes. A 24 h exposure to TGF‐β at concentrations of 0.1, 1 and 10 ng/ml markedly stimulated the synthesis of collagen and non‐collagen protein. Similar increases of glycosaminoglycan production was observed in the same experimental conditions. The distribution of these newly synthesized macromolecules between cell layer and medium was not altered by treatment with TGF‐β. The factor slightly enhanced the proliferation of chondrocytes in these experiments but its potent effect on matrix synthesis was independent of this growth stimulation. These results indicate that articular chondrocytes are target cells for TGF‐β and suggest that this growth factor could play a role in the repair process of cartilage during osteoarticular diseases.

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