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Type IX collagen: A possible function in articular cartilage
Author(s) -
Wotton S.F.,
Duance V.C.,
Fryer P.R.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81307-3
Subject(s) - fibrillogenesis , immunogold labelling , chemistry , fibril , type ii collagen , collagen, type i, alpha 1 , type i collagen , articular cartilage , biophysics , cartilage , collagen fibril , anatomy , microbiology and biotechnology , extracellular matrix , biochemistry , osteoarthritis , pathology , biology , ultrastructure , endocrinology , medicine , alternative medicine
The effect of type IX on in vitro fibrillogenesis of type II collagen indicated that, while not preventing fibrillogenesis, the presence of type IX collagen reduced the size of the type II fibre aggregates. This observation is consistent with the in vivo localisation studies of type IX collagen. Using the immunogold labelling technique, type IX collagen was shown to be located evenly on small fibrils which occur at higher concentration closer to the cell. Therefore type IX collagen may function as a regulator of fibre diameter in articular cartilage.