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Structural specificity of haemosiderin iron cores in iron‐overload diseases
Author(s) -
Mann S.,
Wade V.J.,
Dickson D.P.E.,
Reid N.M.K.,
Ward R.J.,
O'Connell M.,
Peters T.J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81305-x
Subject(s) - chemistry
Haemosiderin iron cores isolated from patients with secondary haemochromatosis have a goethite‐like (α‐FeOOH) crystal structure whereas those from patients with primary haemochromatosis are amorphous Fe (III) oxide. Haemosiderin cores isolated from normal human spleen are crystalline ferrihydrite (5Fe 2 O 3 ·9H 2 O). The disease‐specific structures are significantly different from the ferrihydrite structure of associated ferritin cores. The results are important in understanding the biological processing of iron in pathological states and in the clinical treatment of iron‐overload diseases.