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Endogenous inhibitor of the ADP‐ribosylation of (a) G‐protein(s) as catalyzed by pertussis toxin is present in rat liver
Author(s) -
Hara-Yokoyama Miki,
Furuyama Shunsuke
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81295-x
Subject(s) - pertussis toxin , adp ribosylation , endogeny , toxin , chemistry , biochemistry , g protein , enzyme , receptor , nad+ kinase
The inhibitor activity of the ADP‐ribosylation of (a) G‐protein(s) as catalyzed by pertussis toxin was found in the membrane extract of rat liver. The inhibitor activity was found in the fractions of DEAE‐Sephacel column chromatography at 50–120 mM NaCl. The inhibitor activity is not due to the degradation of NAD nor to the reverse reaction of pertussis toxin (removal of incorporated ADP‐ribose). The present result suggests the presence of an endogenous inhibitor of the ADP‐ribosylation reaction of (a) G‐protein(s).