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Nerve growth factor induces rapid redistribution of F‐actin in PC12 cells
Author(s) -
Paves Heiti,
Neuman Toomas,
Metsis Madis,
Saarma Mart
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81250-x
Subject(s) - nerve growth factor , redistribution (election) , microfilament , epidermal growth factor , microbiology and biotechnology , actin , chemistry , medicine , endocrinology , cytoskeleton , biology , cell , biochemistry , receptor , politics , political science , law
Nerve growth factor (NGF) induces the redistribution of F‐actin in rat pheochromocytoma PC12 cells within 2–10 min, whereas epidermal growth factor (EGF) has no effect on microfilament organization. This redistribution of F‐actin in PC12 cells is not protein synthesis dependent, but can be blocked by methyltransferase inhibitors.