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Characterization of an invertebrate nicotinic acetylcholine receptor gene: The ard gene of Drosophila melanogaster
Author(s) -
Sawruk Erich,
Hermans-Borgmeyer Irm,
Betz Heinrich,
Gundelfinger Eckart D.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81230-4
Subject(s) - gene , intron , drosophila melanogaster , biology , genetics , nicotinic acetylcholine receptor , acetylcholine receptor , exon , receptor
The ard gene encodes a neuronal nicotinic acetylcholine receptor (AChR) protein from Drosophila (ARD protein). Cytogenetically this gene maps at position 64B/C on the left arm of the 3rd chromosome. Five introns interrupt the protein coding region of the gene, and one is found upstream of the translation start site. The ard gene thus contains less introns than vertebrate muscle AChR genes, but, with one exception, the positions of the resident introns are precisely conserved. Implications for the evolution of AChR genes are discussed.