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A unique mRNA species for a regulatory subunit of cAMP‐dependent protein kinase is specifically induced in haploid germ cells
Author(s) -
Øyen Ole,
Scott John D.,
Cadd Gary G.,
McKnight G.Stanley,
Krebs Edwin G.,
Hansson Vidar,
Jahnsen Tore
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81163-3
Subject(s) - spermatid , protein kinase a , biology , protein subunit , microbiology and biotechnology , sperm , gene , kinase , genetics
Cyclic AMP (cAMP) and its action by way of cAMP‐dependent protein kinase is important for sperm motility. Previous studies on germ cells have demonstrated a selective decrease in the amount of type I cAMP‐dependent protein kinase during spermatid development, and that type II was the major form present in elongating spermatids and in mature sperm. This would indicate activation of a gene in haploid germ cells, encoding a regulatory subunit of type II protein kinase. However, haploid expression of such a gene has so far not been shown. In the present study we demonstrate high‐levelled expression of a unique mRNA species for a specific regulatory subunit of type II cAMP‐dependent protein kinase at late stages of spermatogenesis, i.e. during spermatid elongation.