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Iron‐ and manganese‐containing superoxide dismutases can be distinguished by analysis of their primary structures
Author(s) -
Parker Michael W.,
Blake Colin C.F.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81160-8
Subject(s) - manganese , superoxide dismutase , chemistry , primary (astronomy) , biochemistry , enzyme , organic chemistry , physics , astronomy
The iron‐ and manganese‐containing superoxide dismutases have very similar three‐dimensional structures but can be distinguished by various biochemical means. The primary structures of six manganese‐containing and three iron‐containing superoxide dismutases are known. Analysis of the aligned amino acid sequences of these enzymes taken together with structural data from X‐ray diffraction studies demonstrates that the two classes of enzyme can be distinguished on the basis of a small number of single‐site substitutions that are positioned in and close to the active site of the enzyme.