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Stimulation of hepatic T‐kininogen production by interferon
Author(s) -
Itoh Norio,
Yayama Katsutoshi,
Okamoto Hiroshi
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81134-7
Subject(s) - stimulation , chemistry , interferon , medicine , immunology
T‐kininogen is known to be an acute‐phase reactant as well as a kininogen in rat plasma. Three kinds of cytokines, interleukin‐1, tumor necrosis factor and interferon, were assayed for their abilities to stimulate hepatic production of T‐kininogen. Of these cytokines, interferon was able to stimulate hepatic production of T‐kininogen, but few effects were observed for interleukin‐1 and tumor necrosis factor. In addition, the stimulatory effect of interferon was inhibited by tumor necrosis factor. Our data suggest that interferon is a candidate for the leukocyte‐derived factor mediating the acute‐phase response of T‐kininogen.