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Secondary structure of the promastigote surface protease of Leishmania
Author(s) -
Jähnig Fritz,
Etges Robert
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)81035-4
Subject(s) - leishmania , chemistry , protease , leishmania major , microbiology and biotechnology , biophysics , biology , biochemistry , enzyme , parasite hosting , computer science , world wide web
By Raman spectroscopic analysis we have determined the secondary structure of the promastigote surface protease, named PSP or gp63, of Leishmania major . It consist of nearly 50% antiparallel β‐strand, and less than 20% α‐helix. These results are contrasted with the predominantly α‐helical VSGs of the African trypanosomes and the α‐helical metalloprotease thermolysin. The PSP of Leishmania thus represents a novel kind of membrane‐anchored protease.