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An endogenous ligand for the central sulfonylurea receptor
Author(s) -
Virsolvy-Vergine A.,
Brück M.,
Dufour M.,
Cauvin A.,
Lupo B.,
Bataille D.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80986-4
Subject(s) - sulfonylurea , endogeny , chemistry , ligand (biochemistry) , sulfonylurea receptor , receptor , biochemistry , endocrinology , biology , protein subunit , diabetes mellitus , gene
An endogenous ligand for the rat central sulfonylurea receptor has been evidenced in the rat central nervous system. The characteristics of this ligand (extractibility, non‐dialysability, chromatographic behaviour on different media, sensitivity to proteases) indicate that it is a neutral to slightly basic peptide.