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Distinct dystrophin mRNA species are expressed in embryonic and adult mouse skeletal muscle
Author(s) -
Dickson G.,
Pizzey J.A.,
Elsom V.E.,
Love D.,
Davies K.E.,
Walsh F.S.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80982-7
Subject(s) - skeletal muscle , dystrophin , duchenne muscular dystrophy , messenger rna , biology , itga7 , denervation , embryonic stem cell , gene isoform , microbiology and biotechnology , gene expression , myocyte , muscular dystrophy , myosin , gene , endocrinology , genetics
We have examined dystrophin mRNA in embryonic, newborn and adult mouse skeletal muscle. A discrete nerve‐independent increase in mRNA size was observed between embryonic and adult stages, indicating that a developmentally regulated mRNA isoform switch occurs in the expression of the Duchenne muscular dystrophy (DMD) gene in skeletal muscle. These distinct mRNAs are most likely generated via selection of alternative transcriptional start sites or RNA processing pathways. In addition, denervation of adult muscle was without effect on the expression pattern.