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Predictions of linear T‐cell and B‐cell epitopes in proteins encoded by HIV‐1, HIV‐2 and SIV MAC and the conservation of these sites between strains
Author(s) -
Zvelebil Markéta J.J.M.,
Sternberg Michael J.E.,
Cookson John,
Coatest Anthony R.M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80976-1
Subject(s) - antigenicity , epitope , virology , antibody , human immunodeficiency virus (hiv) , biology , antigen , aids vaccines , peptide sequence , hiv vaccine , gene , amino acid , lentivirus , immunology , genetics , viral disease , vaccine trial
An important consideration in the design of vaccines to prevent HIV‐1 infection effective against dilterent strains is the amino acid sequence conservation of antigenic determinants. Even one amino acid change can destroy the antigenicity of a site for the antibody or T‐cell receptor. The comparisons of predicted T‐ and B‐cell epitopes between human HIV‐1, HIV‐2 and monkey SIV MAC AIDS viruses are presented. The three major gene products (env,gag and pol) were examined. A number of epitopes were identical between strains of HIV‐1. Our analysis highlights the problem of designing an effective HIV‐1 and HIV‐2 vaccine and also the problem of testing human vaccines in monkey models.