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Regulation of polypeptide‐chain initiation in rat skeletal muscle Starvation does not alter the activity or phosphorylation state of initiation factor eIF‐2
Author(s) -
Cox Sarah,
Redpath Nicholas T.,
Proud Christopher G.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80946-3
Subject(s) - skeletal muscle , phosphorylation , gastrocnemius muscle , starvation , medicine , protein subunit , endocrinology , chemistry , peptide , protein biosynthesis , biology , microbiology and biotechnology , biochemistry , gene
In rats, 48‐h starvation causes a decrease in the rate of protein synthesis in skeletal (e.g. gastrocnemius) muscle, due largely to impairment of peptide‐chain initiation. In other cell types inhibition of initiation is associated with decreased activity and recycling of initiation factor eIF‐2, and increased phosphorylation of its α‐subunit. However, 48‐h starvation has no effect on the activity or recycling of eIF‐2 measured in extracts of gastrocnemius muscle, or on the level of α‐subunit phosphorylation. The effects of starvation on peptide‐chain initiation in skeletal muscle must therefore involve alterations in other components of the translational machinery.