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Islet amyloid polypeptide: Identification and chromosomal localization of the human gene
Author(s) -
Mosselman S.,
Höppener J.W.M.,
Zandberg J.,
van Mansfeld A.D.M.,
van Kessel A.H.M.Geurts,
Lips C.J.M.,
Jansz H.S.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80922-0
Subject(s) - islet , insulinoma , gene , amyloid (mycology) , biochemistry , peptide sequence , microbiology and biotechnology , biology , amylin , chemistry , pancreas , insulin , endocrinology , botany
Islet or insulinoma amyloid polypeptide (IAPP) is a 37 amino acid polypeptide isolated from pancreatic amyloid. Here, we describe the isolation and partial characterization of the human gene encoding IAPP. The DNA sequence predicts that IAPP is excised from a larger precursor protein and that its carboxy‐terminus is probably amidated. The predicted normally occurring IAPP is identical to the reported polypeptides isolated from pancreatic amyloid, except for the amidated carboxy‐terminus. IAPP specific polyadenylated RNAs of 1.6 kb and 2.1 kb are present in human insulinoma RNA. The human IAPP gene is located on chromosome 12.