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Expression of K channels in Xenopus laevis oocytes injected with poly(A + ) mRNA from the insulin‐secreting β‐cell line, HIT T15
Author(s) -
Ashcroft Frances M.,
Ashcroft S.J.H.,
Berggren P.O.,
Betzholz C.,
Rorsman P.,
Trube G.,
Welsh M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80913-x
Subject(s) - xenopus , tolbutamide , messenger rna , insulin , conductance , chemistry , cell culture , endocrinology , biophysics , microbiology and biotechnology , medicine , biology , biochemistry , gene , physics , genetics , condensed matter physics
Two types of exogenous K channel were identified in Xenopus laevis oocytes injected with poly(A + ) mRNA from the insulin‐secreting cell line HIT T15. One of these was the ATP‐regulated K channel (G channel) as evidenced by its conductance and inhibition by tolbutamide. The other resembled the Ca‐activated K channel from β‐cells.